The effect of barbiturates on the metabolism of phenytoin appears to be variable. Some investigators report an accelerating effect, while others report anzi che no effect. Because the effect of barbiturates on the metabolism of phenytoin is not predictable, phenytoin and barbiturate blood levels should be monitored more frequently if these drugs are given concurrently.
1. Under the influence and appreciably impaired for purposes of driving a motor vehicle or performing tasks requiring alertness and unimpaired judgment and reaction time.
Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
Avoiding tissue extravasation Durante this process is essential as it has been known to cause tissue necrosis. Clinicians should avoid rapid IV injection as it may result Durante respiratory depression, hypotension, and bronchospasm, among other adverse effects.
Hepatic impairment: As clinical data regarding the use of pentobarbital Durante hepatic impairment are lacking, pentobarbital should be used with caution.
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The average daily dose for the barbiturate addict is usually about 1.5 grams. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxicating dosage and fatal dosage becomes smaller.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
Barbiturates are absorbed Con varying degrees following oral, rectal, or parenteral administration. The salts are more more info rapidly absorbed than are the acids.
[2] Studies have demonstrated the superiority of pentobarbital paio to its faster brain penetration and shorter half-life, thereby making it the preferred treatment for refractory status epilepticus.
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